ZBIGNIEW LUDWIK TOPOR

Adjunct Assistant Professor
Department of Cell Biology & Anatomy
Faculty of Medicine
University of Calgary
3330 Hospital Drive NW
Calgary, AB T2N 4N1
Office: 282B HMB
Tel: (403) 220-4516
Fax: (403) 270-8928
Email: zltopor@ucalgary.ca
Website: http://www.ucalgary.ca/~zltopor

RESEARCH INTERESTS

- Stability analysis of physiological systems with multiple feedback loops
- Computer modeling of the respiratory control system
- Development of a novel treatment of central sleep apnea
- Search for underlying pathogenesis of sleep disordered breathing in congestive heart failure using computer modeling and system identification techniques

SIGNIFICANT RESEARCH

Topor, Z.L.; Vasilakos, K; Younes, M; Remmers, J.E. Model based analysis of sleep disordered breathing in congestive heart failure. Respiration Physiology and Neurobiology, 155, (1), 82-92, 15 January 2007.

Topor, Z.L.; Vasilakos, K; Remmers, J.E. Cheyne-Stokes breathing: model based analysis of underlying pathogenesis. Somnologie, 10, Iss. 3, 146, 2006.

Topor, Z.L.; Vasilakos, K; Remmers, J.E. Sleep-disordered breathing in patients with heart failure: a theoretical study. Eur Respir J, 26, Suppl. 49, 358s, 2005.

Topor, Z.L.; Vasilakos, K; Remmers, J.E. Ventilatory instability during sleep: new insights from the computational model. Proceedings of the 27th Annual International Conference of the IEEE-EMBS, Shanghai, China, September 1-4, 2005. ISBN: 0-7803-8741-4.

Topor, Z.L.; Pawlicki, M; Remmers, J.E. A computational model of the human respiratory control system: responses to hypoxia and hypercapnia. Annals of Biomedical Engineering, 32, (11), 1528-1543, 1 November 2004.

Topor, Z.L.; Vasilakos, K; Remmers, J.E. Interaction of two chemoreflex loops in determining ventilatory stability. Nonlinear Studies, 11, (3), 527-541, September 2004.

Topor, Z.L.; Vasilakos, K; Remmers, J.E. Stability analysis of the respiratory control system during sleep. Advances in Experimental Medicine and Biology, 551, 203-209, 2004.

Topor, Z.L.; Johannson, L; Kasprzyk, J; Remmers, J.E. Dynamic ventilatory response to CO2 in congestive heart failure patients with and without central sleep apnea. Journal of Applied Physiology, 91, (1), 408-16, July 2001.

Topor, Z.L.; West, N.H. Control of intermittent ventilation in lower vertebrates. A computer dynamic model. Advances in Experimental Medicine and Biology, 393, 21-2, 1995.