ROGER THOMPSON

Assistant Professor
Departments of Cell Biology & Anatomy and
Clinical Neurosciences
Cumming School of Medicine
University of Calgary
3330 Hospital Drive NW
Calgary, AB T2N 4N1

Tel: (403) 210-6312
Fax: (403) 283-2700
E-mail: rj.thompson@ucalgary.ca
Website: http://www.hbi.ucalgary.ca/members/thompson


Institute Affiliation
Member - Hotchkiss Brain Institute

 

 


RESEARCH INTERESTS

Energy deprivation is an insult observed during several neurological diseases, such as stroke and epilepsy. The goal of my lab is to understand the cellular mechanisms causing neuronal death during oxygen and glucose deprivation and over-activation of glutamate receptors. Focus is on the role that a novel ion channel, pannexin-1 has in permeabilization of the plasma membrane. Ultimately, I would like to understand the connections between loss of mitochondrial function, activation of the pannexin-1 channel, and neuronal death.

Several approaches are used. These include state-of-the-art fluorescent and multi-photon imaging, electrophysiology and molecular biology techniques. These powerful experimental approaches allow for a comprehensive investigation of the molecular mechanisms involved in cell death. We will then use these lessons and models to attack stroke at the in vivo level and ultimately, to design treatments for neurodegeneration.


SIGNIFICANT RESEARCH and/or PUBLICATIONS

Thompson, RJ, Jackson, M, Olah, M, Rungta, R, Hines, D, MacDonald, J and MacVicar, B. (2008). Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus. Science 322:1555-1559.

Thompson, RJ and MacVicar, BA. (2008). Connexin and pannexin hemichannels of neurons and astrocytes. Channels 2:81-86. Review.

Thompson, RJ, Buttigieg, J, Zhang, M, and Nurse, CA. (2007). A rotenone-sensitive site and H2O2 are key components of hypoxia-sensing in neonatal rat adrenomedullary chromaffin cells. Neuroscience. 145:130-141.

Thompson, RJ, Zhou, N, and MacVicar, BA (2006). Ischemia opens neuronal gap junction hemichannels. Science. 312:924-927.

PubMed

CURRENT RESEARCH SUPPORT

Canadian Institutes of Health Research (CIHR)
Heart and Stroke Foundation of Canada
Canadian Stroke Network
Robertson Fund for Cerebral Palsy

ADMINISTRATIVE SUPPORT

Sarah Pittman
Tel: (403) 220-4472
Email: neurosec@ucalgary.ca

GRADUATE STUDENTS

Evelyn Ma