deprivation is an insult observed during several neurological diseases,
such as stroke and epilepsy. The goal of my lab is to understand
the cellular mechanisms causing neuronal death during oxygen and
glucose deprivation and over-activation of glutamate receptors.
Focus is on the role that a novel ion channel, pannexin-1 has in
permeabilization of the plasma membrane. Ultimately, I would like
to understand the connections between loss of mitochondrial function,
activation of the pannexin-1 channel, and neuronal death.
Several approaches are used. These include state-of-the-art fluorescent
and multi-photon imaging, electrophysiology and molecular biology
techniques. These powerful experimental approaches allow for a comprehensive
investigation of the molecular mechanisms involved in cell death.
We will then use these lessons and models to attack stroke at the
in vivo level and ultimately, to design treatments for neurodegeneration.
RESEARCH and/or PUBLICATIONS
Thompson, RJ, Jackson, M, Olah, M, Rungta, R, Hines, D,
MacDonald, J and MacVicar, B. (2008). Activation of Pannexin-1 Hemichannels
Augments Aberrant Bursting in the Hippocampus. Science 322:1555-1559.
Thompson, RJ and MacVicar, BA. (2008). Connexin and pannexin hemichannels
of neurons and astrocytes. Channels 2:81-86. Review.
Thompson, RJ, Buttigieg, J, Zhang, M, and Nurse, CA. (2007). A rotenone-sensitive
site and H2O2 are key components of hypoxia-sensing in neonatal
rat adrenomedullary chromaffin cells. Neuroscience. 145:130-141.
Thompson, RJ, Zhou, N, and MacVicar, BA (2006). Ischemia opens neuronal
gap junction hemichannels. Science. 312:924-927.
Canadian Institutes of Health Research (CIHR)
Heart and Stroke Foundation of Canada
Canadian Stroke Network
Robertson Fund for Cerebral Palsy
Tel: (403) 220-4472