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LEE Institute
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My studies are based on the general working hypothesis that the ubiquitous Cdk5 has tissue-specific functions where Cdk5 activity is regulated by the concerted action of several proteins, primarily by p35, p39 and/or an analogous protein and other regulatory kinases. The initial foci of investigations are tissues of the central and peripheral nervous systems (CNS and PNS) and the male reproductive system. My goals are directed at investigating the regulation and function of Cdk5 in these tissues as it relates to proliferation, differentiation and apoptosis in normal and disease conditions. My studies have already revealed several significant advances in the molecular mechanisms of Cdk5 activation and its relevance in normal tissue development and function as well as in pathological states such as neurodegeneration. I hope to continue to provide meaningful impact in our understanding of the regulation and role of Cdk5 in mammalian cells, and hopefully, my discoveries would translate to significant contributions in the development of novel effective approaches to the diagnosis and/or treatment of diseases associated with altered Cdk5 activity SIGNIFICANT
RESEARCH and/or PUBLICATIONS 2. Rosales, J. L., Virk, K. and Lee, K. -Y. 2008. Vimentin Organization during GTP-induced Secretion is Mediated by Cdk5. J. Biol. Chem. (Under revision). 3. Lee, H. Y., Jung. S. Y., Kim, J. -H., Lee, K. -Y., Suh, P. -G., and Ryu, S. H. 2008. PLD is a Novel Activator of Cdk5 and Modulator of Dendritic Spine Morphogenesis and Synaptogenesis. (Submitted to PLoS ONE: 08-PONE-RA-07317). 4. Cheung, K. -J., Lee, B. -C., Jeong, Y. -G., and Lee, K. -Y. 2008. Tyrosine Hydroxylase Expression and Cdk5 Kinase Activity in Ataxic Cerebellum. Molecular & Cellular Biochemistry. 318, 7-12. 5. Rosales, J. L., Sarker, K., Ho, N., Broniewska, M., Wong, P., Cheng, M., van der Hoorn, F. and Lee, K. -Y. 2007. ODF1 Phosphorylation by Cdk5/p35 Enhances ODF1-OIP1 Interaction. Cell. Physiol. & Biochem. 20, 311-318. 6. Rosales, J. L. and Lee, K. -Y. 2006. Extraneuronal Roles of Cyclin-dependent Kinase 5. BioEssays 28, 1028-1034. 7. Rosales, J. L., Joel D. Ernst and Lee, K. -Y. 2004. GTP-dependent Secretion from Neutrophils is Regulated by Cdk5. J. Biol. Chem. 279, 59932-59936. 8. Rosales,
J. L., Lee, B. -C., Modarressi, M., Sarker, K., Lee, K. Y., Jeong,
Y. -G., Oko, R. and Lee, K. -Y. 2004. Outer Dense Fibers (ODF) Serve
as Functional Target for Cdk5/p35 in the Developing Sperm Tail.
J. Biol. Chem. 279, 1224-1232. Canadian Institutes
of Health Research (CIHR) ADMINISTRATIVE SUPPORT Laurie Loro RESEARCH PERSONNEL Drs. Jesusa Rosales, Jennifer Wilson, Smaranda Abaco GRADUATE STUDENTS Nathan Barcey
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